羟基乙酸联合1319nmNd:YAG激光面部除皱的临床及基础研究(1)
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[摘要]目的：观察羟基乙酸联合1319nmNd:YAG激光治疗面部皱纹的效果并探讨其除皱机制。方法：30例患者，随机分为两组，A组予果酸治疗组，B组为联合治疗组，予果酸联合1319nmNd:YAG激光治疗；选择40只SD大鼠，随机分空白对照组，光老化组，果酸治疗组及联合治疗组各10只，联合治疗组予果酸联合1319nmNd:YAG激光治疗并比较不同组大鼠皮肤组织学改变。结果：联合治疗组有效率达80%，而果酸治疗组达60%。组间有效率比较，差异具有统计学意义(χ2＝3.801，P<0.05)；联合治疗组高于果酸治疗组。造模光老化大鼠真皮胶原变性、断裂、减少、排列紊乱，经激光及果酸治疗后得到改善,联合治疗改善更明显。结论：1319nmNd:YAG激光联合羟基乙酸面部除皱疗效优于单纯羟基乙酸治疗。
[关键词]羟基乙酸；1319nmNd:YAG激光；皱纹；面部
[中图分类号]R622 R730.57 [文献标识码]A [文章编号]1008-6455(2012)01-0063-03
Basic and clinical research of the treatment of wrinkle reduction in face used by glycolicacid and 1319nmNd:YAG laser
LI Xue-li1,HUANG Yu-cheng1,YANG li1,LI Tian-ju1,LI Fu-guang2
(1.Department of Dermatology,The People′s Hospital,Zhengzhou 450003,Henan,China;2.Department of Immunology,The Medical College of Zhengzhou University)
Abstract: Objective To investigate the effectiveness of glycolicacid and 1319nm Nd:YAG laser in wrinkle reduction of face and explore its possible mechanism. Methods 30 patients were divided into two groups randomly. Group A was given only glycolicacid treatment, group B was treated with glycolicacid and 1319nmNd:YAG laser. At the same time 40 SD-rats were randomly divided into control group, photoaged group,glycolicacid treatment group and laser- glycolicacid treatment group,laser-glycolicacid treatment group was treated by 1319nmNd:YAG laser and glycolica- cid. Results The effectiveness ratio of two groups were 80.0%, 60.0% respectively, and there was a significantly statistic difference between them.(χ2＝3.801，P<0.05).And the degeneration,reduction and disorder of dremal collagen improved after 1319nm-Nd:YAG laser and glycolicacid treatment, laser- glycolicacid treatment gr- oup was better in effect than glycolicacid treatment group. Conclusion 1319nm Nd: YAG laser comebined with glycolicacid had been proven to be better for wrinkle reduction in face.
Key words:glycolicacid;1319nmND:YAG laser;wrinkle; face
随着年龄的增加和紫外线等环境因素的影响,皮下的胶原纤维会发生减少、变细、断裂等改变,使皮肤变得粗糙、松弛、下垂,从而出现皱纹、色斑、毛细血管扩张、良性甚至恶性肿瘤等老化表现[1]。化学换肤是将化学试剂涂在皮肤表面，导致皮肤可控地被破坏和剥脱，启动伤口愈合机制，真皮胶原增生，皮肤发生重建，达到抗皮肤老化的作用[2]，而1319nmNd:YAG激光主要通过深层加热刺激胶原蛋白再生 ......
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