高糖血症、高糖饮食和急性血糖升高对心血管系统功能的影响(3)
[12]Ceriello A,Motz E.Is oxidative stress the pathogenic mechanism underlying insulin resistance,diabetes,and cardiovascular disease?The common soil hypothesis revisited.Arterioscler Thromb Vasc Biol，2004，24:816-822.
[13]Halliwell B,Gutteridge J.Free radicals in biology and medicine.4th ed.New York:Oxford University Press，2007.
[14]Hudson BI,Wendt T,Bucciarelli LG,Rong LL,Naka Y,Yan SF,Schmidt AM.Diabetic vascular disease:its all the rage. Antioxid Redox Signal，2005，7:1588-1600.
, 百拇医药
[15]Janssen-Heininger YM,Poynter ME,Baeuerle PA.Recent advances towards understanding redox mechanisms in the activation of nuclear factor κB.Free Radicals Biol Med，2000，28：1317-1327.
[16]Khan BV,Harrison DG,Olbrych MT,Alexander RW & Medford RM.Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.Proc Natl Acad Sci，1996，93:9114-9149.
, 百拇医药
[17]Stehouwer CD,Lambert J,Donker AJ & van Hinsbergh VW.Endothelial dysfunction and pathogenesis of diabetic angiopathy.Cardiovasc Res 1997，34：55-68.
[18]Sratton IM,Adler AJ,Neil HA et al.Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35).Br Med J，2000，321:405-412.
[19]Gordin D,Forsblom C,Ronnback M et al.Acute hyperglycaemia induces an inflammatory response in young patients with type 1 diabetes.Anna Med，2008，40:627-32.
, http://www.100md.com
[20]Marfella R,Esposito K,Giunta R,et al.Circulating adhesion molecules in humans:role of hyperglycaemia and hyperinsulinemia. Circulation，2000，101:2247-2251.
[21]Morohoshi M,Fujisawa K,Uchimura I,Numano F.Glucose-dependent interleukin 6 and tumor necrosis factor production by human peripheral blood monocytes in vitro.Diabetes，1996，45：945-949.
[22]Esposito K,Nappo F,Marfella R,et al.Inflammatory cytokine concentrations are acutely increased by hyperglycaemia in humans:role of oxidative stress.Circulation，2003，107:206-207.
, 百拇医药
[23]Giugliano D,Marfella R,Coppola L,et al.Vascular effects of acute hyperglycemia in humans are reversed by L-arginine.Evidence for reduced availability of nitric oxide during hyperglycemia.Circulation，1997，95:1783-1790.
[24]Ceriello A,Quagliaro L,DAmico M,et al.Acute hyperglycaemia induces nitrotyrosine formation and apoptosis in perfused heart from rat.Diabetes，2002，51:1076-1082.
[25]Sechi LA.Mechanisms of insulin resistance in rat models of hypertension and their relationships with salt sensitivity.J Hypertens，1999,17:1229-1237.
, 百拇医药
[26]Preuss HG.Diet,genetics and hypertension.J Am Coll Nutr，1997，16:296-305.
[27]Roysommuti S,Khongnakha T,Jirakulsomchok D,et al.Excess dietary glucose alters renal function before increasing arterial pressure and inducing insulin resistance.AJH 2002，15:773-779.
[28]Preuss HG,Zein M,MacArthy P,et al.Sugar-induced blood pressure elevations over the lifespan of three substrains of Wistar rats.J Am Coll Nutr，1998，17:36-47.
, http://www.100md.com
[29]Bunag RD,Tomita T,Sasaki S.Chronic sucrose ingestion induces mild hypertension and tachycardia in rats.Hypertension，1983，5:218-225.
[30]Sechi LA.Mechanisms of insulin resistance in rat models of hypertension and their relationships with salt sensitivity.J Hypertens,1999,17:1229-1237.
【收稿日期】2011-07-25, http://www.100md.com(王丽娜)
[13]Halliwell B,Gutteridge J.Free radicals in biology and medicine.4th ed.New York:Oxford University Press，2007.
[14]Hudson BI,Wendt T,Bucciarelli LG,Rong LL,Naka Y,Yan SF,Schmidt AM.Diabetic vascular disease:its all the rage. Antioxid Redox Signal，2005，7:1588-1600.
, 百拇医药
[15]Janssen-Heininger YM,Poynter ME,Baeuerle PA.Recent advances towards understanding redox mechanisms in the activation of nuclear factor κB.Free Radicals Biol Med，2000，28：1317-1327.
[16]Khan BV,Harrison DG,Olbrych MT,Alexander RW & Medford RM.Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.Proc Natl Acad Sci，1996，93:9114-9149.
, 百拇医药
[17]Stehouwer CD,Lambert J,Donker AJ & van Hinsbergh VW.Endothelial dysfunction and pathogenesis of diabetic angiopathy.Cardiovasc Res 1997，34：55-68.
[18]Sratton IM,Adler AJ,Neil HA et al.Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35).Br Med J，2000，321:405-412.
[19]Gordin D,Forsblom C,Ronnback M et al.Acute hyperglycaemia induces an inflammatory response in young patients with type 1 diabetes.Anna Med，2008，40:627-32.
, http://www.100md.com
[20]Marfella R,Esposito K,Giunta R,et al.Circulating adhesion molecules in humans:role of hyperglycaemia and hyperinsulinemia. Circulation，2000，101:2247-2251.
[21]Morohoshi M,Fujisawa K,Uchimura I,Numano F.Glucose-dependent interleukin 6 and tumor necrosis factor production by human peripheral blood monocytes in vitro.Diabetes，1996，45：945-949.
[22]Esposito K,Nappo F,Marfella R,et al.Inflammatory cytokine concentrations are acutely increased by hyperglycaemia in humans:role of oxidative stress.Circulation，2003，107:206-207.
, 百拇医药
[23]Giugliano D,Marfella R,Coppola L,et al.Vascular effects of acute hyperglycemia in humans are reversed by L-arginine.Evidence for reduced availability of nitric oxide during hyperglycemia.Circulation，1997，95:1783-1790.
[24]Ceriello A,Quagliaro L,DAmico M,et al.Acute hyperglycaemia induces nitrotyrosine formation and apoptosis in perfused heart from rat.Diabetes，2002，51:1076-1082.
[25]Sechi LA.Mechanisms of insulin resistance in rat models of hypertension and their relationships with salt sensitivity.J Hypertens，1999,17:1229-1237.
, 百拇医药
[26]Preuss HG.Diet,genetics and hypertension.J Am Coll Nutr，1997，16:296-305.
[27]Roysommuti S,Khongnakha T,Jirakulsomchok D,et al.Excess dietary glucose alters renal function before increasing arterial pressure and inducing insulin resistance.AJH 2002，15:773-779.
[28]Preuss HG,Zein M,MacArthy P,et al.Sugar-induced blood pressure elevations over the lifespan of three substrains of Wistar rats.J Am Coll Nutr，1998，17:36-47.
, http://www.100md.com
[29]Bunag RD,Tomita T,Sasaki S.Chronic sucrose ingestion induces mild hypertension and tachycardia in rats.Hypertension，1983，5:218-225.
[30]Sechi LA.Mechanisms of insulin resistance in rat models of hypertension and their relationships with salt sensitivity.J Hypertens,1999,17:1229-1237.
【收稿日期】2011-07-25, http://www.100md.com(王丽娜)