糖皮质激素联合盐酸氨溴索治疗分泌性中耳炎临床效果及不良反应(1)
【摘要】 目的：分析分泌型中耳炎患者应用糖皮质激素与盐酸氨溴索联合治疗效果、不良反应情况。方法：选取2018年2月-2019年2月笔者所在医院诊治的85例分泌型中耳炎患者，按随机数字表法分为两组，对照组(42例)予盐酸氨溴索，研究组(43例)予糖皮质激素与盐酸氨溴索联合方案，分析两组临床效果、不良反应情况。结果：治疗后研究组总有效率为95.35%，显著高于对照组，差异有统计学意义(P<0.05);研究组治疗后TNF-α为(0.73±0.36)ng/ml，IL-1β为(1.56±0.52)pg/ml，均低于对照组，差异均有统计学意义(P<0.05);研究组听力不稳发生率为2.33%，低于对照组的19.05%，差异有统计学意义(P<0.05)。结论：分泌型中耳炎患者应用糖皮质激素与盐酸氨溴索联合治疗能提高临床效果，降低炎症指标水平，具有较高用药安全性。
【关键词】 分泌性中耳炎 糖皮质激素 盐酸氨溴索 临床效果 不良反应 听力不稳
doi：10.14033/j.cnki.cfmr.2020.03.008 文献标识码 B 文章编号 1674-6805(2020)03-00-02
[Abstract] Objective： To analyze the efficacy， adverse reactions of Glucocorticoid combined with Ambroxol Hydrochloride in secretory otitis media. Method： From February 2018 to February 2019， a total of 85 patients with secretory otitis media were treated in our hospital. According to the random number table method， patients were divided into two groups. The control group (42 cases) was given Ambroxol Hydrochloride， and the research group (43 cases) was given Glucocorticoid combined with Ambroxol Hydrochloride. Then the clinical effects， adverse reactions of the two groups were analyzed. Result： After treatment， the total effective rate of the research group was 95.35%， which was higher than that of the control group， and the difference was statistically significant (P<0.05). The TNF-α was (0.73±0.36) ng/ml， IL-1β was (1.56±0.52) pg/ml in the research group， which were lower than those of the control group， and the differences were statistically significant (P<0.05). The incidence of hearing instability was 2.33% in the research group， which was lower than 19.05% of the control group， and the difference was statistically significant (P<0.05). Conclusion： The combination of Glucocorticoid and Ambroxol Hydrochloride in secretory otitis media can improve the clinical effect， reduce the level of inflammatory indicators， and have a higher medication safety.
[Key words] Secretory otitis media Glucocorticoids Ambroxol Hydrochloride Clinical effects Adverse reactions Hearing instability
First-author’s address： Stomatological Hospital Affiliated to Foshan University of Science and Technology， Foshan 528000， China
分泌型中耳炎主要由于咽鼓管阻塞導致中耳发炎，造成中耳产生积液及听力下降的非化脓性炎性疾病[1-2]。分泌型中耳炎主要临床表现为耳鸣、轻微耳痛、听力降低、耳内闭塞及闷胀感等，严重影响患者正常生活质量[3-4]。对分泌型中耳炎疾病患者，临床通常采用药物治疗方案。为有效提高疾病治疗效果，本研究对2018年2月-2019年2月笔者所在医院诊治的85例分泌型中耳炎患者行糖皮质激素与盐酸氨溴索联合治疗，分析如下。
1 资料与方法
1.1 一般资料
选取2018年2月-2019年2月笔者所在医院诊治的85例分泌型中耳炎患者。纳入标准：确诊为分泌型中耳炎;资料完整，能够主动配合。排除标准：服用其他药物;心理及精神疾病;严重肝肾疾病。按随机数字表法分为两组，对照组42例，男24例，女18例;年龄35～76岁，平均(46.14±8.37)岁;病程3～10年，平均(6.93±2.39)年。研究组43例，男25例，女18例;年龄34～75岁，平均(47.23±8.18)岁;病程3～11年，平均(6.76±2.46)年。两组性别、病程、年龄等一般资料比较，差异均无统计学意义(P>0.05)。研究经医学伦理会批准，患者均签署相关知情同意书。, 百拇医药(王顺平)
【关键词】 分泌性中耳炎 糖皮质激素 盐酸氨溴索 临床效果 不良反应 听力不稳
doi：10.14033/j.cnki.cfmr.2020.03.008 文献标识码 B 文章编号 1674-6805(2020)03-00-02
[Abstract] Objective： To analyze the efficacy， adverse reactions of Glucocorticoid combined with Ambroxol Hydrochloride in secretory otitis media. Method： From February 2018 to February 2019， a total of 85 patients with secretory otitis media were treated in our hospital. According to the random number table method， patients were divided into two groups. The control group (42 cases) was given Ambroxol Hydrochloride， and the research group (43 cases) was given Glucocorticoid combined with Ambroxol Hydrochloride. Then the clinical effects， adverse reactions of the two groups were analyzed. Result： After treatment， the total effective rate of the research group was 95.35%， which was higher than that of the control group， and the difference was statistically significant (P<0.05). The TNF-α was (0.73±0.36) ng/ml， IL-1β was (1.56±0.52) pg/ml in the research group， which were lower than those of the control group， and the differences were statistically significant (P<0.05). The incidence of hearing instability was 2.33% in the research group， which was lower than 19.05% of the control group， and the difference was statistically significant (P<0.05). Conclusion： The combination of Glucocorticoid and Ambroxol Hydrochloride in secretory otitis media can improve the clinical effect， reduce the level of inflammatory indicators， and have a higher medication safety.
[Key words] Secretory otitis media Glucocorticoids Ambroxol Hydrochloride Clinical effects Adverse reactions Hearing instability
First-author’s address： Stomatological Hospital Affiliated to Foshan University of Science and Technology， Foshan 528000， China
分泌型中耳炎主要由于咽鼓管阻塞導致中耳发炎，造成中耳产生积液及听力下降的非化脓性炎性疾病[1-2]。分泌型中耳炎主要临床表现为耳鸣、轻微耳痛、听力降低、耳内闭塞及闷胀感等，严重影响患者正常生活质量[3-4]。对分泌型中耳炎疾病患者，临床通常采用药物治疗方案。为有效提高疾病治疗效果，本研究对2018年2月-2019年2月笔者所在医院诊治的85例分泌型中耳炎患者行糖皮质激素与盐酸氨溴索联合治疗，分析如下。
1 资料与方法
1.1 一般资料
选取2018年2月-2019年2月笔者所在医院诊治的85例分泌型中耳炎患者。纳入标准：确诊为分泌型中耳炎;资料完整，能够主动配合。排除标准：服用其他药物;心理及精神疾病;严重肝肾疾病。按随机数字表法分为两组，对照组42例，男24例，女18例;年龄35～76岁，平均(46.14±8.37)岁;病程3～10年，平均(6.93±2.39)年。研究组43例，男25例，女18例;年龄34～75岁，平均(47.23±8.18)岁;病程3～11年，平均(6.76±2.46)年。两组性别、病程、年龄等一般资料比较，差异均无统计学意义(P>0.05)。研究经医学伦理会批准，患者均签署相关知情同意书。, 百拇医药(王顺平)
参见：首页 > 医疗版 > 疾病专题 > 耳鼻喉科 > 耳疾病 > 中耳疾病 > 中耳炎 > 分泌性中耳炎